看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。# N6 Y. o( k# n
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Currently available feasibility data for possible combination strategies.
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) ]7 C6 `$ U1 b( h% q6 dCombination Feasibility according to preliminary data
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Bevacizumab + sorafenib Yes, reduced dose
6 g; h# b& C* p# j, o+ vBevacizumab + sunitinib† No 9 x( A9 u0 ~5 w
Bevacizumab + temsirolimus Yes : X' Z9 } s d
Bevacizumab + everolimus Yes
/ e- u& u: r5 @% }6 i hSorafenib + sunitinib ?
5 J* d% U2 G) ?, M1 k0 uSorafenib + temsirolimus Yes, reduced dose " w8 L& V3 h9 K6 Z9 T8 X! b
Sorafenib + everolimus Yes, reduced dose
5 t. ? E4 G+ i1 _' |: pSunitinib + temsirolimus† No
; C& u9 q8 i$ m r4 c+ \: w! zSunitinib + everolimus ? & f1 U: r5 {1 k
Temsirolimus + everolimus ? $ J2 f' A* y7 a/ X4 Z7 p
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& @6 B/ |$ {0 ]) v†Led to US FDA warning.
! W! Y/ a8 }# G7 K% R?: As yet unattempted combination.
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