发给老马备查:! z+ Y5 s) W" Q2 ^) g6 i- g
滴水察海(69304838) 15:23:235 ^$ A8 w# T5 s0 z. E- _4 N
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
3 z) ^5 g/ h3 l3 B0 c/ T吉非替尼和S-1连用的依据+ V2 b: s7 |$ \. q) ^' K, d
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
% D: H: h/ `; }: f! W1 K- n是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
! k, p, J& t8 {; O& B这样是不是推理出,耐药后,可以用S-1和培美了?2 V) O0 v2 G( X0 R; H- P9 X# W
结论:
+ C) y! o4 K2 ? n1 y如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |