发给老马备查:
. w4 ]6 o7 |( H4 ]% _, G0 K4 e! s滴水察海(69304838) 15:23:23
+ R% x0 A* p; @, @- s' n老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
+ f$ p% \, |% w" p吉非替尼和S-1连用的依据
7 r2 q; u8 T' B! A5 NGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.! v ~7 o1 d) H7 J9 k
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
+ M1 H. |' C; {) j这样是不是推理出,耐药后,可以用S-1和培美了?
! \8 ?) _6 f* z* _ ~3 Z" _结论:: }- H7 }, |/ t9 m% F- }, A+ c/ S
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |